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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1605175
Species: Homo sapiens
CRRD Object: Gene
Symbol: IQSEC3
Name: IQ motif and Sec7 domain ArfGEF 3
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases methylationEXP 6480464CTDValproic Acid results in increased methylation of IQSEC3 gene

PMID:28853863, PMID:29154799, PMID:29201983
affects splicingISORGD:15931916480464CTDValproic Acid affects the splicing of IQSEC3 mRNA

PMID:29427782
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.