Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   


CRRD ID: 2078
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Ak4
Name: adenylate kinase 4
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:16065916480464CTDValproic Acid affects the expression of AK4 mRNA

decreases expressionISORGD:16065916480464CTDValproic Acid results in decreased expression of AK4 mRNA

PMID:23179753, PMID:25192806, PMID:29154799, PMID:29501571
increases expressionISORGD:16065916480464CTDValproic Acid results in increased expression of AK4 mRNA

PMID:23179753, PMID:24383497, PMID:26272509, PMID:28001369
increases methylationISORGD:16065916480464CTDValproic Acid results in increased methylation of AK4 gene

PMID:29154799, PMID:29501571
multiple interactionsISORGD:16065916480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AK4 mRNA

Go Back to source page   Continue to Ontology report


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.