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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2198
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Bckdk
Name: branched chain ketoacid dehydrogenase kinase
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:692146480464CTDValproic Acid affects the expression of BCKDK mRNA

PMID:25979313
increases expressionISORGD:692146480464CTDValproic Acid results in increased expression of BCKDK mRNA

PMID:23179753
increases methylationISORGD:692146480464CTDValproic Acid results in increased methylation of BCKDK gene

PMID:29154799
multiple interactionsISORGD:692146480464CTD[Hydralazine co-treated with Valproic Acid] results in increased expression of BCKDK mRNA

PMID:17183730
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.