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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 61312
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Timp2
Name: TIMP metallopeptidase inhibitor 2
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:7339066480464CTDValproic Acid affects the expression of TIMP2 mRNA

PMID:25979313
decreases expressionISORGD:7339066480464CTDValproic Acid results in decreased expression of TIMP2 mRNA

PMID:29154799
increases expressionISORGD:7339066480464CTDValproic Acid results in increased expression of TIMP2 mRNA

PMID:23179753, PMID:24935251, PMID:27188386, PMID:28001369
increases methylationISORGD:7339066480464CTDValproic Acid results in increased methylation of TIMP2 gene

PMID:29154799
multiple interactionsISORGD:7339066480464CTD[Hydralazine co-treated with Valproic Acid] results in increased expression of TIMP2 mRNA

PMID:17183730
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.