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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620585
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Elovl6
Name: ELOVL fatty acid elongase 6
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:13322056480464CTDValproic Acid affects the expression of ELOVL6 mRNA

PMID:17963808
affects expressionISORGD:13452216480464CTDValproic Acid affects the expression of ELOVL6 mRNA

PMID:25979313
decreases expressionISORGD:13452216480464CTDValproic Acid results in decreased expression of ELOVL6 mRNA

PMID:23179753, PMID:27188386, PMID:29154799
increases expressionISORGD:13452216480464CTDValproic Acid results in increased expression of ELOVL6 mRNA, Valproic Acid results in increased expression of ELOVL6 protein

PMID:24935251, PMID:30003287
multiple interactionsISORGD:13452216480464CTD[Hydralazine co-treated with Valproic Acid] results in increased expression of ELOVL6 mRNA, NR1H3 protein affects the reaction [Valproic Acid results in increased expression of ELOVL6 mRNA]

PMID:17183730, PMID:30003287
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.