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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620660
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Ptpn6
Name: protein tyrosine phosphatase, non-receptor type 6
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISOCRRD:7341886480464CTDValproic Acid results in decreased expression of PTPN6 mRNA

PMID:29154799
increases expressionISOCRRD:7341886480464CTDValproic Acid results in increased expression of PTPN6 mRNA

PMID:23527032
increases methylationISOCRRD:7341886480464CTDValproic Acid results in increased methylation of PTPN6 gene

PMID:29154799
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.