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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69152
Species: Homo sapiens
CRRD Object: Gene
Symbol: EGFR
Name: epidermal growth factor receptor
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases methylationEXP 6480464CTDValproic Acid results in decreased methylation of EGFR gene

PMID:29154799
increases expressionEXP 6480464CTDValproic Acid results in increased expression of EGFR mRNA

PMID:23179753, PMID:24383497, PMID:24935251, PMID:26272509, PMID:27188386, PMID:28001369
multiple interactionsEXP 6480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EGFR mRNA

PMID:27188386
decreases expressionISORGD:105116480464CTDValproic Acid results in decreased expression of EGFR mRNA

PMID:24535564
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.