GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2965
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Kdr
Name: kinase insert domain receptor
Acc ID: CHEBI:4027
Term: cyclophosphamide
Definition: A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom.
Chemical ID: MESH:D003520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDCyclophosphamide results in decreased expression of KDR mRNA

Cyclophosphamide results in decreased expression of KDR protein

PMID:19701751
increases expressionEXP 6480464CTDCyclophosphamide results in increased expression of KDR mRNA

PMID:18632792
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.