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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730973
Species: Mus musculus
CRRD Object: Gene
Symbol: Srebf2
Name: sterol regulatory element binding factor 2
Acc ID: CHEBI:40303
Term: lovastatin
Definition: A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom).
Chemical ID: MESH:D008148
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[Dietary Fats co-treated with Lovastatin] affects the expression of SREBF2 mRNA

PMID:29852127
increases localizationISORGD:7309726480464CTDLovastatin results in increased localization of SREBF2 protein

PMID:11728391
multiple interactionsISORGD:13077516480464CTD[Cholesterol deficiency co-treated with Lovastatin] results in increased activity of SREBF2 protein, Cholesterol inhibits the reaction [[Cholesterol deficiency co-treated with Lovastatin] results in increased activity of SREBF2 protein]

PMID:20578043
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.