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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 61312
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Timp2
Name: TIMP metallopeptidase inhibitor 2
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7339066480464CTDCyclosporine results in decreased expression of TIMP2 mRNA

PMID:27989131
increases expressionISORGD:7339066480464CTDCyclosporine results in increased expression of TIMP2 mRNA

PMID:20106945, PMID:21632981, PMID:25562108
multiple interactionsISORGD:7339066480464CTD[Cyclosporine co-treated with Cholic Acids] affects the expression of TIMP2 mRNA

PMID:27344345
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.