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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621612
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nts
Name: neurotensin
Acc ID: CHEBI:41072
Term: 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
Definition: An indole that has formula C25H24N4O2.
Chemical ID: MESH:C070515
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityEXP 6480464CTDbisindolylmaleimide I results in increased activity of NTS protein

PMID:18313772
increases activityISORGD:13190926480464CTDbisindolylmaleimide I results in increased activity of NTS protein

PMID:18313772
multiple interactionsISORGD:13190926480464CTDbisindolylmaleimide I affects the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates], bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein], Sucrose promotes the reaction [bisindolylmaleimide I results in increased activity of NTS protein]

PMID:18313772
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.