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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 70913
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Abcc5
Name: ATP binding cassette subfamily C member 5
Acc ID: CHEBI:41423
Term: celecoxib
Definition: A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and p-tolyl groups, respectively. A cyclooxygenase-2 inhibitor, it is used in the treatment of arthritis.
Chemical ID: MESH:C105934
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:7343636480464CTDCelecoxib results in increased expression of ABCC5 mRNA, Celecoxib results in increased expression of ABCC5 protein

PMID:18690847
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.