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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1563633
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Edem1
Name: ER degradation enhancing alpha-mannosidase like protein 1
Acc ID: CHEBI:41500
Term: 4-phenylbutyric acid
Definition: A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Chemical ID: MESH:C075773
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:15578136480464CTD4-phenylbutyric acid results in decreased expression of EDEM1 mRNA

PMID:28698385
multiple interactionsISORGD:15578136480464CTD4-phenylbutyric acid promotes the reaction [LEPR gene mutant form results in increased expression of EDEM1 mRNA]

PMID:23274897
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.