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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621032
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr0b2
Name: nuclear receptor subfamily 0, group B, member 2
Acc ID: CHEBI:41774
Term: tamoxifen
Definition: A stilbenoid that has formula 371.51460.
Chemical ID: MESH:D013629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:7328746480464CTDTamoxifen affects the expression of NR0B2 mRNA

PMID:20937368
increases expressionISORGD:7328736480464CTDTamoxifen results in increased expression of NR0B2 mRNA

PMID:15342952, PMID:17175557
increases expressionISORGD:7328746480464CTDTamoxifen results in increased expression of NR0B2 mRNA

PMID:17555576
multiple interactionsISORGD:7328736480464CTDTamoxifen inhibits the reaction [ESR1 protein binds to NR0B2 protein]

PMID:23665804
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.