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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 731369
Species: Mus musculus
CRRD Object: Gene
Symbol: Tff2
Name: trefoil factor 2 (spasmolytic protein 1)
Acc ID: CHEBI:41774
Term: tamoxifen
Definition: A stilbenoid that has formula 371.51460.
Chemical ID: MESH:D013629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7313686480464CTDTamoxifen results in decreased expression of TFF2 mRNA

PMID:20696891
increases expressionISORGD:7313686480464CTDTamoxifen results in increased expression of TFF2 mRNA

PMID:15590111
multiple interactionsISORGD:7313686480464CTDTamoxifen promotes the reaction [NCOR1 protein binds to TFF2 promoter]

PMID:20696891
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.