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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621032
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr0b2
Name: nuclear receptor subfamily 0, group B, member 2
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDDexamethasone results in decreased expression of NR0B2 mRNA

PMID:20832446, PMID:29222744
multiple interactionsISORGD:7328746480464CTD[Dexamethasone co-treated with Ibuprofen] results in decreased expression of NR0B2 mRNA, [Dexamethasone co-treated with Ibuprofen] results in decreased expression of NR0B2 protein

PMID:29222744
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.