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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 68328
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Slc2a5
Name: solute carrier family 2 member 5
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDDexamethasone affects the expression of SLC2A5 mRNA

PMID:15102944
increases expressionEXP 6480464CTDDexamethasone results in increased expression of SLC2A5 mRNA

PMID:20032058
multiple interactionsEXP 6480464CTDDexamethasone promotes the reaction [Fructose results in increased activity of SLC2A5 protein], Dexamethasone promotes the reaction [Fructose results in increased expression of SLC2A5 mRNA], Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [Fructose results in increased activity of SLC2A5 protein]], Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [Fructose results in increased expression of SLC2A5 mRNA]], Testosterone inhibits the reaction [Dexamethasone results in increased expression of SLC2A5 mRNA]

PMID:18556366, PMID:20032058
multiple interactionsISORGD:684566480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SLC2A5 mRNA

PMID:28628672
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.