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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 70069
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cxcl2
Name: C-X-C motif chemokine ligand 2
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDDexamethasone inhibits the reaction [Ozone results in increased expression of CXCL2 mRNA]

Dexamethasone promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CXCL2 mRNA]

PMID:18590720, PMID:7737418
decreases expressionISOCRRD:7356216480464CTDDexamethasone results in decreased expression of CXCL2 mRNA

PMID:25047013
increases expressionISOCRRD:7331186480464CTDDexamethasone results in increased expression of CXCL2 mRNA

PMID:25900201
multiple interactionsISOCRRD:7331186480464CTD[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL2 mRNA

Amiodarone inhibits the reaction [Dexamethasone results in increased expression of CXCL2 mRNA]

Dexamethasone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL2 protein]

Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL2 protein]

Dexamethasone inhibits the reaction [Ozone results in increased expression of CXCL2 protein]

TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL2 mRNA]

PMID:14754758, PMID:22154906, PMID:23503329, PMID:25900201, PMID:30849337
multiple interactionsISOCRRD:7356216480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of CXCL2 mRNA

[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CXCL2 mRNA

[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CXCL2 mRNA

PMID:28628672
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.