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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1349671
Species: Homo sapiens
CRRD Object: Gene
Symbol: TAF1
Name: TATA-box binding protein associated factor 1
Acc ID: CHEBI:42265
Term: epoxomicin
Definition: A tripeptide consisting of an Ile-Ile-Thr-NH2 sequence N-substituted on the threonamide amidic nitrogen with a (2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl group and with acetyl and methyl groups on the nitrogen of the isoleucine residue distal to the threonamide; a naturally occurring selective proteasome inhibitor with anti-inflammatory activity.
Chemical ID: MESH:C078846
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDepoxomicin inhibits the reaction [5-(4-((6-(allyloxy)-2, 5, 7, 8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2, 4-dione results in decreased expression of TAF1 protein]

PMID:17409431
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.