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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621032
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr0b2
Name: nuclear receptor subfamily 0, group B, member 2
Acc ID: CHEBI:43602
Term: obeticholic acid
Definition: A dihydroxy-5beta-cholanic acid that is chenodeoxycholic acid carrying an additional ethyl substituent at the 6alpha-position. A semi-synthetic bile acid which acts as a farnesoid X receptor agonist and is used for treatment of primary biliary cholangitis.
Chemical ID: MESH:C464660
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDobeticholic acid results in increased expression of NR0B2 mRNA, obeticholic acid results in increased expression of NR0B2 protein

PMID:15644430, PMID:15860571, PMID:15980055, PMID:27255380
multiple interactionsEXP 6480464CTDNR0B2 protein affects the reaction [obeticholic acid inhibits the reaction [JUND protein binds to TIMP1 promoter]], NR0B2 protein affects the reaction [obeticholic acid results in decreased expression of and results in decreased secretion of TIMP1 protein], obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of NR0B2 mRNA]

PMID:15860571, PMID:27255380
increases expressionISORGD:7328736480464CTDobeticholic acid results in increased expression of NR0B2 mRNA

PMID:15911693, PMID:27939613
increases expressionISORGD:7328746480464CTDobeticholic acid results in increased expression of NR0B2 mRNA, obeticholic acid results in increased expression of NR0B2 protein

PMID:26655953
multiple interactionsISORGD:7328736480464CTDobeticholic acid promotes the reaction [PRMT2 protein binds to NR0B2 promoter]

PMID:15911693
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.