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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 733705
Species: Homo sapiens
CRRD Object: Gene
Symbol: CTNNB1
Name: catenin beta 1
Acc ID: CHEBI:44185
Term: methotrexate
Definition: A pteridine that has formula C20H22N8O5.
Chemical ID: MESH:D008727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDMethotrexate promotes the reaction [6-bromoindirubin-3'-oxime results in decreased phosphorylation of CTNNB1 protein]

PMID:19727391
decreases expressionISORGD:704876480464CTDMethotrexate results in decreased expression of CTNNB1 protein

PMID:25187349
multiple interactionsISORGD:704876480464CTD[Methotrexate co-treated with Leucovorin] results in increased expression of CTNNB1 protein

PMID:25187349
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.