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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1321077
Species: Mus musculus
CRRD Object: Gene
Symbol: Mark4
Name: MAP/microtubule affinity regulating kinase 4
Acc ID: CHEBI:44616
Term: afimoxifene
Definition: A tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen.
Chemical ID: MESH:C016601
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mark4decreases response to substanceISORGD:13210766480464CTDMARK4 results in decreased susceptibility to afimoxifene

PMID:21233418
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.