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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1353925
Species: Homo sapiens
CRRD Object: Gene
Symbol: PIK3R3
Name: phosphoinositide-3-kinase regulatory subunit 3
Acc ID: CHEBI:44616
Term: afimoxifene
Definition: A tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen.
Chemical ID: MESH:C016601
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDafimoxifene inhibits the reaction [Estrogens results in decreased expression of PIK3R3 mRNA]

PMID:21233418
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