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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621032
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr0b2
Name: nuclear receptor subfamily 0, group B, member 2
Acc ID: CHEBI:45285
Term: pyrazinecarboxamide
Definition: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.
Chemical ID: MESH:D011718
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDPyrazinamide results in decreased expression of NR0B2 mRNA

PMID:27255380
multiple interactionsEXP 6480464CTDobeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of NR0B2 mRNA]

PMID:27255380
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.