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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2482
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp7a1
Name: cytochrome P450 family 7 subfamily A member 1
Acc ID: CHEBI:45409
Term: ritonavir
Definition: An L-valine derivative that is an antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS, it is often used as a fixed-dose combination with another protease inhibitor, lopinavir. Also used in combination with dasabuvir sodium hydrate, ombitasvir and paritaprevir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver.
Chemical ID: MESH:D019438
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDRitonavir results in decreased expression of CYP7A1 mRNA

PMID:17719200
decreases expressionISORGD:692106480464CTDRitonavir results in decreased expression of CYP7A1 mRNA

PMID:26626330
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.