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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1583832
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Pgd
Name: phosphogluconate dehydrogenase
Acc ID: CHEBI:4551
Term: digoxin
Definition: A cardenolide glycoside that is digitoxin beta-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small.
Chemical ID: MESH:D004077
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityEXP 6480464CTDDigoxin results in decreased activity of PGD protein

PMID:26820767
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.