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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69152
Species: Homo sapiens
CRRD Object: Gene
Symbol: EGFR
Name: epidermal growth factor receptor
Acc ID: CHEBI:45716
Term: vorinostat
Definition: A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Chemical ID: MESH:C111237
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases phosphorylationEXP 6480464CTDvorinostat results in decreased phosphorylation of EGFR protein

PMID:20531243
decreases expressionISORGD:25436480464CTDvorinostat results in decreased expression of EGFR mRNA, vorinostat results in decreased expression of EGFR protein

PMID:21389970
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.