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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1344166
Species: Homo sapiens
CRRD Object: Gene
Symbol: OPA1
Name: OPA1 mitochondrial dynamin like GTPase
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of OPA1 mRNA

PMID:21420995, PMID:22230336, PMID:25704631
affects expressionISORGD:15514166480464CTDAcetaminophen affects the expression of OPA1 mRNA

PMID:17562736
decreases expressionISORGD:7084236480464CTDAcetaminophen results in decreased expression of OPA1 protein

PMID:27792760
multiple interactionsISORGD:7084236480464CTDAICA ribonucleotide inhibits the reaction [Acetaminophen results in decreased expression of OPA1 protein]

PMID:27792760
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.