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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621032
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr0b2
Name: nuclear receptor subfamily 0, group B, member 2
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:7328746480464CTDAcetaminophen affects the expression of NR0B2 mRNA

PMID:17562736
affects response to substanceISORGD:7328746480464CTDNR0B2 protein affects the susceptibility to Acetaminophen

PMID:29943110
decreases expressionISORGD:7328746480464CTDAcetaminophen results in decreased expression of NR0B2 mRNA

PMID:29943110
multiple interactionsISORGD:7328746480464CTD[Clofibrate co-treated with Acetaminophen] affects the expression of NR0B2 mRNA, GADD45B protein affects the reaction [NR0B2 protein affects the reaction [Acetaminophen results in increased expression of GPT protein]], NR0B2 protein affects the reaction [Acetaminophen results in increased expression of GADD45B mRNA], NR0B2 protein affects the reaction [Acetaminophen results in increased expression of GPT protein], NR0B2 protein affects the reaction [Acetaminophen results in increased phosphorylation of MAP2K4 protein], PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of NR0B2 mRNA]

PMID:17585979, PMID:29943110
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.