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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621295
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Mvk
Name: mevalonate kinase
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:7320326480464CTDAcetaminophen affects the expression of MVK mRNA

PMID:17562736
decreases expressionISORGD:7320316480464CTDAcetaminophen results in decreased expression of MVK mRNA

PMID:29067470
increases expressionISORGD:7320326480464CTDAcetaminophen results in increased expression of MVK mRNA

PMID:29246445
multiple interactionsISORGD:7320326480464CTDPANX1 gene mutant form inhibits the reaction [Acetaminophen results in increased expression of MVK mRNA]

PMID:29246445
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.