GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621714
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Sptan1
Name: spectrin, alpha, non-erythrocytic 1
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISOCRRD:16144266480464CTDAcetaminophen affects the expression of SPTAN1 mRNA

PMID:17562736
decreases expressionISOCRRD:7332396480464CTDAcetaminophen results in decreased expression of SPTAN1 mRNA

Acetaminophen results in decreased expression of SPTAN1 protein

PMID:22230336, PMID:26690555
increases degradationISOCRRD:16144266480464CTDAcetaminophen results in increased degradation of SPTAN1 protein

PMID:16871587
increases expressionISOCRRD:7332396480464CTDAcetaminophen results in increased expression of SPTAN1 mRNA

PMID:21420995
multiple interactionsISOCRRD:16144266480464CTDCAST protein inhibits the reaction [Acetaminophen results in increased degradation of SPTAN1 protein]

PMID:16871587
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.