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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 68321
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Sec61a1
Name: Sec61 translocon alpha 1 subunit
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects response to substanceISORGD:13518136480464CTDSEC61A1 gene polymorphism affects the susceptibility to Acetaminophen

PMID:26104854
increases expressionISORGD:13518136480464CTDAcetaminophen results in increased expression of SEC61A1 mRNA

PMID:22230336, PMID:29067470
multiple interactionsISORGD:684436480464CTD[Clofibrate co-treated with Acetaminophen] affects the expression of SEC61A1 mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SEC61A1 mRNA]

PMID:17585979
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.