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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730881
Species: Homo sapiens
CRRD Object: Gene
Symbol: HRAS
Name: HRas proto-oncogene, GTPase
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:107306480464CTDAcetaminophen affects the expression of HRAS mRNA

PMID:17562736
increases activityISORGD:107306480464CTDAcetaminophen results in increased activity of HRAS protein

PMID:19739265
multiple interactionsISORGD:107306480464CTDGliotoxin inhibits the reaction [Acetaminophen results in increased activity of HRAS protein], manumycin inhibits the reaction [Acetaminophen results in increased activity of HRAS protein]

PMID:19739265
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.