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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1311990
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Ap4s1
Name: adaptor related protein complex 4 subunit sigma 1
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13481896480464CTDFluorouracil results in decreased expression of AP4S1 mRNA

PMID:16510598
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