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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3543
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Rbp1
Name: retinol binding protein 1
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects response to substanceISORGD:7323916480464CTDRBP1 protein affects the susceptibility to Fluorouracil

PMID:15352031
decreases expressionISORGD:7323916480464CTDFluorouracil results in decreased expression of RBP1 protein

PMID:15352031
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.