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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621821
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Fen1
Name: flap structure-specific endonuclease 1
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects response to substanceISORGD:7326796480464CTDFEN1 affects the susceptibility to Fluorouracil

PMID:15067352
increases expressionISORGD:7326796480464CTDFluorouracil results in increased expression of FEN1 mRNA

PMID:15109396
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.