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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 70913
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Abcc5
Name: ATP binding cassette subfamily C member 5
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases response to substanceISORGD:7343636480464CTDABCC5 protein results in decreased susceptibility to Fluorouracil

PMID:19077464
multiple interactionsISORGD:7343636480464CTD5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [ABCC5 protein results in decreased susceptibility to Fluorouracil], ABCC5 protein results in increased export of and results in decreased susceptibility to Fluorouracil

PMID:15897250
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.