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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 61312
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Timp2
Name: TIMP metallopeptidase inhibitor 2
Acc ID: CHEBI:46557
Term: zoledronic acid
Definition: An imidazole compound having a 2,2-bis(phosphono)-2-hydroxyethane-1-yl substituent at the 1-position.
Chemical ID: MESH:C088658
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:621786480464CTDzoledronic acid results in increased expression of TIMP2 mRNA

PMID:28871336
increases expressionISORGD:7339066480464CTDZoledronic Acid results in increased expression of TIMP2 protein

PMID:28871336
multiple interactionsISORGD:621786480464CTDFenofibrate inhibits the reaction [Zoledronic Acid results in increased expression of TIMP2 mRNA], SLC27A2 gene mutant form inhibits the reaction [Zoledronic Acid results in increased expression of TIMP2 mRNA]

PMID:28871336
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.