GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2809
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Foxa3
Name: forkhead box A3
Acc ID: CHEBI:4659
Term: disulfiram
Definition: An organic disulfide that results from the formal oxidative dimerisation of N,N-diethyldithiocarbamic acid. A multi-enzyme inhibitor that is used in alcohol aversion therapy and also exhibits anticancer properties.
Chemical ID: MESH:D004221
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISOCRRD:16057256480464CTD[Disulfiram binds to Copper] which results in decreased expression of FOXA3 mRNA

PMID:24690739
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.