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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3001
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Lepr
Name: leptin receptor
Acc ID: CHEBI:4670
Term: dobutamine
Definition: A catecholamine that is 4-(3-aminobutyl)phenol in which one of the hydrogens attached to the nitrogen is substituted by a 2-(3,4-dihydroxyphenyl)ethyl group. A beta1-adrenergic receptor agonist that has cardiac stimulant action without evoking vasoconstriction or tachycardia, it is used as the hydrochloride to increase the contractility of the heart in the management of acute heart failure.
Chemical ID: MESH:D004280
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects response to substanceISOCRRD:108656480464CTDLEPR protein affects the susceptibility to Dobutamine

PMID:20175764
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.