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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1309875
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Lig3
Name: DNA ligase 3
Acc ID: CHEBI:47217
Term: arsane
Definition: An arsine that has formula 77.94542.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13204526480464CTDArsenic results in decreased expression of LIG3 mRNA, Arsenic results in decreased expression of LIG3 protein

PMID:21332098
multiple interactionsISORGD:13204526480464CTDCurcumin inhibits the reaction [Arsenic results in decreased expression of LIG3 mRNA], Curcumin inhibits the reaction [Arsenic results in decreased expression of LIG3 protein]

PMID:21332098
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.