GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2459
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:47381
Term: diclofenac
Definition: A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Chemical ID: MESH:D004008
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISOCRRD:7357116480464CTDDiclofenac metabolite results in decreased activity of CYP1A2 protein

PMID:28960974
increases expressionISOCRRD:7357116480464CTDDiclofenac results in increased expression of CYP1A2 mRNA

Diclofenac results in increased expression of CYP1A2 protein

PMID:21784029
multiple interactionsISOCRRD:7357116480464CTD[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac

PMID:23397584
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.