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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 619573
Species: Mus musculus
CRRD Object: Gene
Symbol: Slc22a6
Name: solute carrier family 22 (organic anion transporter), member 6
Acc ID: CHEBI:47426
Term: furosemide
Definition: A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.
Chemical ID: MESH:D005665
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a6decreases activityEXP 6480464CTDFurosemide results in decreased activity of SLC22A6 protein

PMID:18216144
Slc22a6increases secretionEXP 6480464CTDSLC22A6 protein results in increased secretion of Furosemide

PMID:18216144
Slc22a6increases expressionISORGD:693386480464CTDFurosemide results in increased expression of SLC22A6 protein

PMID:12897087
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.