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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 14100757
Species: Sus scrofa
CRRD Object: Gene
Symbol: CYP3A29
Name: cytochrome P450 3A29
Acc ID: CHEBI:47519
Term: ketoconazole
Definition: A racemate consisting of equimolar amounts of (2R,4S)- and (2S,4R)-ketoconazole.
Chemical ID: MESH:D007654
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A29multiple interactionsEXP 6480464CTDKetoconazole inhibits the reaction [CYP3A29 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone], Ketoconazole inhibits the reaction [CYP3A29 protein results in increased hydroxylation of Testosterone], Ketoconazole inhibits the reaction [CYP3A29 protein results in increased oxidation of Nifedipine]

PMID:20863320
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