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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2012
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Acadm
Name: acyl-CoA dehydrogenase medium chain
Acc ID: CHEBI:47612
Term: bezafibrate
Definition: A monocarboxylic acid amide obtained by the formal condensation of the carboxy group of 4-chlorobenzoic acid with the amino group of 2-[4-(2-aminoethyl)phenoxy]-2-methylpropanoic acid. Benafibrate is used for the treatment of hyperlipidaemia.
Chemical ID: MESH:D001629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDBezafibrate inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of ACADM mRNA]

PMID:26190035
increases expressionISORGD:100576480464CTDBezafibrate results in increased expression of ACADM mRNA

PMID:19124612
multiple interactionsISORGD:100576480464CTDBezafibrate inhibits the reaction [CYP19A1 gene mutant form results in decreased expression of ACADM mRNA], Bezafibrate inhibits the reaction [SLC27A2 gene mutant form results in decreased expression of ACADM mRNA], PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACADM mRNA]

PMID:11929713, PMID:19124612
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.