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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 68945
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp4a1
Name: cytochrome P450, family 4, subfamily a, polypeptide 1
Acc ID: CHEBI:47612
Term: bezafibrate
Definition: A monocarboxylic acid amide obtained by the formal condensation of the carboxy group of 4-chlorobenzoic acid with the amino group of 2-[4-(2-aminoethyl)phenoxy]-2-methylpropanoic acid. Benafibrate is used for the treatment of hyperlipidaemia.
Chemical ID: MESH:D001629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDBezafibrate results in increased expression of CYP4A1 mRNA

PMID:19647067
multiple interactionsEXP 6480464CTDAcetylcysteine promotes the reaction [Bezafibrate results in increased expression of CYP4A1 mRNA]

PMID:19647067
increases expressionISORGD:16233166480464CTDBezafibrate results in increased expression of CYP4A22 mRNA

PMID:15447978
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.