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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730881
Species: Homo sapiens
CRRD Object: Gene
Symbol: HRAS
Name: HRas proto-oncogene, GTPase
Acc ID: CHEBI:4775
Term: ellagic acid
Definition: An organic heterotetracyclic compound resulting from the formal dimerisation of gallic acid by oxidative aromatic coupling with intramolecular lactonisation of both carboxylic acid groups of the resulting biaryl. It is found in many fruits and vegetables, including raspberries, strawberries, cranberries, and pomegranates.
Chemical ID: MESH:D004610
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:107306480464CTD[Ellagic Acid co-treated with Plant Extracts] inhibits the reaction [9, 10-Dimethyl-1, 2-benzanthracene results in increased mutagenesis of HRAS gene], [Ellagic Acid co-treated with resveratrol] inhibits the reaction [9, 10-Dimethyl-1, 2-benzanthracene results in increased mutagenesis of HRAS gene]

PMID:20103723
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.