GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1305911
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Ap1s1
Name: adaptor related protein complex 1 subunit sigma 1
Acc ID: CHEBI:47780
Term: clomipramine
Definition: A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
Chemical ID: MESH:D002997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISOCRRD:13142266480464CTDClomipramine results in decreased expression of AP1S1 mRNA

PMID:15342952, PMID:17175557
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.