CRRD ID: 1305911
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Ap1s1
Name: adaptor related protein complex 1 subunit sigma 1
Acc ID: CHEBI:47780
Term: clomipramine
Definition: A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
Chemical ID: MESH:D002997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISOCRRD:13142266480464CTDClomipramine results in decreased expression of AP1S1 mRNA

PMID:15342952, PMID:17175557
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.