GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620196
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Mmp13
Name: matrix metallopeptidase 13
Acc ID: CHEBI:47977
Term: 2-amino-2-deoxy-D-glucopyranose
Definition: A D-glucosamine whose structure comprises D-glucopyranose having an amino substituent at position 2.
Chemical ID: MESH:D005944
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDGlucosamine results in increased expression of MMP13 mRNA

PMID:17109745
multiple interactionsEXP 6480464CTDGlucosamine inhibits the reaction [IL1B results in increased expression of MMP13 mRNA]

IL1B promotes the reaction [Glucosamine results in increased expression of MMP13 mRNA]

PMID:17109745
affects expressionISOCRRD:13432676480464CTDGlucosamine analog affects the expression of MMP13 mRNA

PMID:17337215
multiple interactionsISOCRRD:13432676480464CTDGlucosamine analog inhibits the reaction [IL1B protein results in increased expression of MMP13]

Glucosamine analog inhibits the reaction [IL1B results in increased expression of and results in increased secretion of MMP13 protein]

Glucosamine analog inhibits the reaction [IL1B results in increased expression of MMP13 mRNA]

Glucosamine analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP13 mRNA]

Glucosamine inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]

Glucosamine inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]

PMID:15144122, PMID:17337215, PMID:17925024, PMID:18080321, PMID:19656660
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.