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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621032
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr0b2
Name: nuclear receptor subfamily 0, group B, member 2
Acc ID: CHEBI:4806
Term: (-)-epigallocatechin 3-gallate
Definition: A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.
Chemical ID: MESH:C045651
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDepigallocatechin gallate results in decreased expression of NR0B2 mRNA

PMID:23146761
increases expressionISORGD:7328736480464CTDepigallocatechin gallate results in increased expression of NR0B2 mRNA

PMID:22178739
increases expressionISORGD:7328746480464CTDepigallocatechin gallate results in increased expression of NR0B2 mRNA

PMID:22178739
multiple interactionsISORGD:7328736480464CTDepigallocatechin gallate inhibits the reaction [Chenodeoxycholic Acid results in increased expression of NR0B2 mRNA], epigallocatechin gallate inhibits the reaction [GW 4064 results in increased expression of NR0B2 mRNA]

PMID:22178739
multiple interactionsISORGD:7328746480464CTDNR1H4 protein affects the reaction [epigallocatechin gallate results in increased expression of NR0B2 mRNA]

PMID:22178739
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.